Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719394 | 0.91 | GPR119 (0.39) | GPR119IRAK4AAK1TBK1SLC34A1 | |
| SCHEMBL4719875 | 0.91 | MKNK1 (0.39) | GPR119CDK2TBK1 | |
| SCHEMBL4719029 | 0.90 | GPR119 (0.40) | GPR119IRAK4CCNA2CDK2CDK5 | |
| SCHEMBL389989 | 0.89 | GPR119 (0.61) | GPR119IRAK4CCNA2CDK2CDK5 | |
| SCHEMBL4723185 | 0.89 | TBK1 (0.38) | GPR119TBK1 | |
| SCHEMBL4719508 | 0.89 | GPR119 (0.41) | GPR119IRAK4CCNA2CDK2CDK5 | |
| SCHEMBL4724482 | 0.89 | GPR119 (0.38) | GPR119CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL4724030 | 0.89 | KDR (0.39) | IRAK4TBK1 | |
| SCHEMBL4723049 | 0.88 | GPR119 (0.39) | GPR119IRAK4CCNA2CDK2CDK5 | |
| SCHEMBL4718652 | 0.88 | TBK1 (0.39) | GPR119CCNA2CDK2CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |