Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | CCND3 | P30281 | 4/20 | 0.33 |
| ▸ | CDK7 | P50613 | 4/20 | 0.33 |
| ▸ | CDK9 | P50750 | 4/20 | 0.33 |
| ▸ | CCNH | P51946 | 4/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL386353 | 0.89 | GPR119 (0.47) | GPR119TBK1IKBKE | |
| SCHEMBL4720580 | 0.89 | TBK1 (0.37) | GPR119TBK1AAK1ACACB | |
| SCHEMBL4720573 | 0.89 | GPR119 (0.48) | GPR119TBK1AAK1CCNA2CDK2 | |
| SCHEMBL4723661 | 0.87 | GPR119 (0.38) | GPR119TBK1ACACB | |
| SCHEMBL4719875 | 0.87 | MKNK1 (0.39) | GPR119TBK1CDK2ACACB | |
| SCHEMBL4763290 | 0.86 | TBK1 (0.40) | GPR119TBK1AAK1CDK2ACACB | |
| SCHEMBL4723185 | 0.85 | TBK1 (0.38) | GPR119TBK1ACACBKCNH2 | |
| SCHEMBL4722370 | 0.85 | TBK1 (0.39) | GPR119TBK1CDK2ACACB | |
| SCHEMBL4718652 | 0.85 | TBK1 (0.39) | GPR119TBK1CCNA2CDK2CDK5 | |
| SCHEMBL4724030 | 0.85 | KDR (0.39) | TBK1CDK7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |