Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.32 |
| ▸ | SLC16A1 | P53985 | 3/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721353 | 0.89 | KAT2B (0.38) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4722058 | 0.88 | PDE3B (0.39) | SCDSMN1; SMN2RAF1BRAFEPHX2 | |
| SCHEMBL4720999 | 0.88 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4725015 | 0.87 | BRD4 (0.38) | RAF1BRAFEPHX2KMT2A | |
| SCHEMBL4721347 | 0.87 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4720140 | 0.87 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4721889 | 0.87 | SMN1; SMN2 (0.32) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4721242 | 0.86 | RAD52 (0.38) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4722089 | 0.86 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4722917 | 0.86 | SMN1; SMN2 (0.33) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |