Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.38 |
| ▸ | THRA | P10827 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | TPH1 | P17752 | 2/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3311074 | 0.99 | THRB (0.37) | THRBTHRAPPARGGPR35TPH1 | |
| SCHEMBL10679766 | 0.82 | THRB (0.46) | THRBTHRAPPARGTPH1SLC7A5 | |
| SCHEMBL4717339 | 0.80 | ALDH1A1 (0.42) | THRBTHRATPH1SLC7A5MMP8 | |
| Hydrochloric Acid SCHEMBL3316938 | 0.79 | TPH1 (0.42) | THRBTHRATPH1SLC7A5MMP8 | |
| SCHEMBL5234664 | 0.79 | CPB2 (0.40) | THRBTHRATPH1SLC7A5CYP4F2 | |
| SCHEMBL4035263 | 0.78 | TPH1 (0.42) | THRBTHRAPPARGTPH1SLC7A5 | |
| SCHEMBL4035478 | 0.78 | TPH1 (0.42) | THRBTHRAPPARGTPH1SLC7A5 | |
| SCHEMBL3877275 | 0.78 | TPH1 (0.42) | THRBTHRAPPARGTPH1SLC7A5 | |
| SCHEMBL4717979 | 0.77 | SMN1; SMN2 (0.43) | TPH1SLC7A5CYP4F2CYP4A11 | |
| Hydrochloric Acid SCHEMBL3312834 | 0.76 | SMN1; SMN2 (0.43) | TPH1SLC7A5CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558600-B1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-05-07 | — | — | EP | disclosed |
| EP-1558600-A1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004037810-A1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-05-06 | — | — | WO | disclosed |