Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 9/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391175 | 0.89 | GPR119 (0.42) | ACACBKCNH2TBK1GPR119 | |
| SCHEMBL28781409 | 0.85 | ACACB (0.41) | ACACBKCNH2TBK1 | |
| SCHEMBL4721984 | 0.82 | HTR2C (0.40) | ACACBTBK1GPR119PRCP | |
| SCHEMBL4719875 | 0.81 | MKNK1 (0.39) | ACACBTBK1GPR119 | |
| SCHEMBL4723296 | 0.81 | TBK1 (0.39) | ACACBTBK1GPR119 | |
| SCHEMBL4763290 | 0.81 | TBK1 (0.40) | ACACBTBK1GPR119 | |
| SCHEMBL4719868 | 0.80 | SSTR4 (0.35) | ACACBTBK1GPR119SSTR4 | |
| SCHEMBL4723287 | 0.79 | TBK1 (0.39) | ACACBTBK1GPR119 | |
| SCHEMBL4719783 | 0.78 | TBK1 (0.39) | ACACBTBK1GPR119ABL1 | |
| SCHEMBL4722370 | 0.78 | TBK1 (0.39) | ACACBTBK1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |