Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4724930 | 1.00 | PDE7A (0.37) | PDE7AP2RX7BRD9BRD4ITGB2 | |
| SCHEMBL14102030 | 0.88 | AR (0.37) | BRD9BRD4 | |
| SCHEMBL4718873 | 0.84 | P2RX7 (0.35) | PDE7AP2RX7ITGB2ICAM1ITGAL | |
| SCHEMBL4718877 | 0.84 | P2RX7 (0.35) | PDE7AP2RX7ITGB2ICAM1ITGAL | |
| SCHEMBL4722067 | 0.83 | P2RX7 (0.39) | PDE7AP2RX7ITGB2ICAM1ITGAL | |
| SCHEMBL4722070 | 0.83 | P2RX7 (0.39) | PDE7AP2RX7ITGB2ICAM1ITGAL | |
| SCHEMBL4718889 | 0.81 | F10 (0.34) | PDE7AP2RX7MCHR1SOS1 | |
| SCHEMBL4718893 | 0.81 | F10 (0.34) | PDE7AP2RX7MCHR1SOS1 | |
| SCHEMBL4722849 | 0.80 | BRD4 (0.45) | BRD9BRD4 | |
| SCHEMBL4722458 | 0.78 | ABL1 (0.39) | PDE7AP2RX7ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |