Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776382 | 0.84 | SMN1; SMN2 (0.56) | PDGFRBPDGFRAMAPTALDH1A1LMNA | |
| SCHEMBL1748617 | 0.80 | RIPK1 (0.57) | PDGFRBPDGFRATDO2ADRA1AADRA1B | |
| SCHEMBL2476987 | 0.80 | CHEK1 (0.54) | PDGFRBPDGFRAMAPTALDH1A1LMNA | |
| SCHEMBL4725457 | 0.77 | RAB9A (0.52) | PDGFRBMAPTALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL1778743 | 0.75 | GSK3B (0.61) | PDGFRBPDGFRAMAPTALDH1A1LMNA | |
| SCHEMBL28292542 | 0.75 | PDGFRB (0.58) | PDGFRBPDGFRAMAPTALDH1A1LMNA | |
| SCHEMBL7713938 | 0.71 | AR (0.64) | PDGFRBPDGFRAMAPTALDH1A1LMNA | |
| SCHEMBL8171583 | 0.71 | PDGFRB (1.00) | PDGFRBPDGFRAMAPTALDH1A1LMNA | |
| Ammonia Solution, Strong SCHEMBL28872779 | 0.70 | AR (0.62) | PDGFRBPDGFRAMAPTALDH1A1LMNA | |
| SCHEMBL18463852 | 0.70 | ITK (0.57) | PDGFRBPDGFRAMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008014249-A2 | IMPROVED PREPARATIONS OF 2 -SUBSTITUTED PYRROLO [2, 3-B] PYRAZINE ( 4, 7 -DIAZAINDOLE ) COMPOUNDS | SANOFI-AVENTIS (FR) | 2008-01-31 | — | — | WO | disclosed |