Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | PDE2A | O00408 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776375 | 0.84 | RAB9A (0.50) | RAB9ANPC1PDE2APDE3BPDE3A | |
| SCHEMBL374022 | 0.80 | RAB9A (0.74) | RAB9ANPC1MAPTALDH1A1HPGD | |
| SCHEMBL29631691 | 0.80 | RAB9A (0.74) | RAB9ANPC1MAPTALDH1A1HPGD | |
| SCHEMBL4725465 | 0.77 | PDGFRB (0.55) | PDE2APDE3BPDE3AMAPTALDH1A1 | |
| SCHEMBL4794773 | 0.76 | GSK3B (0.60) | RAB9ANPC1ITKCYP19A1GSK3B | |
| SCHEMBL5423443 | 0.76 | NPC1 (0.58) | RAB9ANPC1MAPTALDH1A1HPGD | |
| SCHEMBL2186023 | 0.75 | RAB9A (0.57) | RAB9ANPC1MAPTALDH1A1HPGD | |
| SCHEMBL4780727 | 0.75 | RIPK1 (0.59) | RAB9ANPC1ITKCYP19A1GSK3B | |
| SCHEMBL31603909 | 0.75 | KDR (0.54) | RAB9ANPC1MAPTALDH1A1HPGD | |
| SCHEMBL14012751 | 0.75 | KDR (0.54) | RAB9ANPC1MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008014249-A2 | IMPROVED PREPARATIONS OF 2 -SUBSTITUTED PYRROLO [2, 3-B] PYRAZINE ( 4, 7 -DIAZAINDOLE ) COMPOUNDS | SANOFI-AVENTIS (FR) | 2008-01-31 | — | — | WO | disclosed |