Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 12/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780125 | 0.85 | FAAH (0.51) | FAAHCYP2D6 | |
| SCHEMBL4727972 | 0.84 | AOC3 (0.54) | FAAHCYP2D6CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4729308 | 0.84 | FAAH (0.46) | FAAHCYP2D6HTT | |
| SCHEMBL14292081 | 0.84 | CYP2D6 (0.61) | FAAHCYP2D6 | |
| SCHEMBL4726854 | 0.84 | CYP2D6 (0.61) | FAAHCYP2D6 | |
| SCHEMBL4847869 | 0.84 | CYP2D6 (0.61) | FAAHCYP2D6 | |
| SCHEMBL4831753 | 0.82 | STK17A (0.49) | FAAH | |
| SCHEMBL4727781 | 0.82 | FAAH (0.56) | FAAH | |
| SCHEMBL4801761 | 0.81 | CDK2 (0.50) | FAAHHTT | |
| SCHEMBL4797527 | 0.81 | AURKA (0.49) | FAAHCYP2D6CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |