Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14292081 | 0.86 | CYP2D6 (0.61) | FAAHCYP2D6 | |
| SCHEMBL4847869 | 0.86 | CYP2D6 (0.61) | FAAHCYP2D6 | |
| SCHEMBL4726854 | 0.86 | CYP2D6 (0.61) | FAAHCYP2D6 | |
| SCHEMBL4725654 | 0.84 | FAAH (0.49) | FAAHCYP2D6HTT | |
| SCHEMBL4779880 | 0.83 | FAAH (0.49) | FAAHCYP2D6 | |
| SCHEMBL4730814 | 0.80 | CDK2 (0.52) | FAAHALDH1A1MAPTCYP2D6 | |
| SCHEMBL4798934 | 0.79 | AURKA (0.54) | FAAHCYP2D6 | |
| SCHEMBL4728067 | 0.78 | ADRB2 (0.40) | FAAHALDH1A1CYP2D6NR3C2 | |
| SCHEMBL4779928 | 0.77 | AURKA (0.52) | FAAHALDH1A1MAPTCYP2D6HTT | |
| SCHEMBL4797882 | 0.77 | CDK4 (0.51) | FAAHMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |