Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726263 | 0.78 | KDM4E (0.40) | CYP1A2KDM4ECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4906644 | 0.76 | PSEN1 (0.43) | CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| Hydrochloric Acid SCHEMBL4899189 | 0.75 | PSEN1 (0.43) | CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL15543495 | 0.74 | NPSR1 (0.50) | CYP1A2KDM4ECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30001281 | 0.74 | NPSR1 (0.50) | CYP1A2KDM4ECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4904071 | 0.74 | CYP1A2 (0.51) | CYP1A2KDM4ECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL17309330 | 0.73 | KDM4A (0.43) | — | |
| SCHEMBL14258733 | 0.73 | SCN9A (0.43) | CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL29186948 | 0.72 | S1PR1 (0.36) | CYP1A2KDM4ECYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL4904250 | 0.72 | SCN9A (0.42) | CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058391-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-03-06 | — | — | US | disclosed |
| US-20080058391-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-03-06 | — | — | US | disclosed |
| US-20080058391-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-03-06 | — | — | US | disclosed |
| WO-2008017691-A1 | PYRIDINE DERIVATIVES AS SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2008-02-14 | — | — | WO | disclosed |
| WO-2008017691-A1 | PYRIDINE DERIVATIVES AS SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058391-A1 | NOVEL COMPOUNDS | HCN3, KCNN3, HCN4 | CYP1A2 1926/4885KDM4E 2966/4885CYP3A4 803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.