Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TOP2A | P11388 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219508 | 0.85 | LMNA (0.40) | LMNASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL6093637 | 0.80 | F3 (0.55) | LMNASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL4731550 | 0.77 | ALDH1A1 (0.47) | LMNASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL28608967 | 0.76 | F3 (0.56) | LMNASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL4728657 | 0.76 | HPGDS (0.46) | LMNASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL4729596 | 0.75 | PDGFRB (0.50) | LMNASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL1124609 | 0.75 | P4HTM (0.58) | LMNASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL20139654 | 0.75 | P4HTM (0.58) | LMNASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL30034522 | 0.75 | P4HTM (0.58) | LMNASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL28609817 | 0.75 | GSK3B (0.60) | LMNASMN1; SMN2MAPTPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |