Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GPR183 | P32249 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726429 | 0.85 | LMNA (0.51) | LMNAMAPTSMN1; SMN2POLBGAA | |
| SCHEMBL8214695 | 0.81 | ALDH1A1 (0.40) | LMNAMAPTSMN1; SMN2POLBGAA | |
| SCHEMBL8219294 | 0.81 | HPGDS (0.41) | SMN1; SMN2KMT2A | |
| SCHEMBL8213322 | 0.80 | PDGFRB (0.42) | LMNAMAPTSMN1; SMN2POLBGAA | |
| SCHEMBL8213285 | 0.79 | MAPT (0.45) | MAPTPOLBALDH1A1KMT2ANPC1 | |
| SCHEMBL8266779 | 0.79 | MAOB (0.44) | LMNAMAPTSMN1; SMN2POLBGAA | |
| SCHEMBL8211974 | 0.78 | GRM1 (0.47) | LMNAMAPTSMN1; SMN2POLBGAA | |
| SCHEMBL8221266 | 0.77 | RAB9A (0.49) | LMNAMAPTSMN1; SMN2POLBGAA | |
| SCHEMBL8216865 | 0.77 | RAB9A (0.36) | LMNAMAPTSMN1; SMN2POLBGAA | |
| SCHEMBL8215908 | 0.77 | CNR2 (0.36) | LMNAMAPTSMN1; SMN2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |