Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 10/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213322 | 0.86 | PDGFRB (0.42) | PDGFRBPDGFRAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL4731550 | 0.86 | ALDH1A1 (0.47) | PDGFRBPDGFRAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL4728657 | 0.85 | HPGDS (0.46) | PDGFRBPDGFRAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL4730660 | 0.81 | SMN1; SMN2 (0.41) | KMT2ASMN1; SMN2MEN1ALDH1A1HTT | |
| SCHEMBL4730340 | 0.81 | HPGD (0.41) | PDGFRBPDGFRAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5511163 | 0.79 | RAB9A (0.60) | PDGFRBPDGFRAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5509239 | 0.76 | ALDH1A1 (0.56) | KMT2ASMN1; SMN2MEN1ALDH1A1HTT | |
| SCHEMBL16052805 | 0.76 | ALDH1A1 (0.56) | KMT2ASMN1; SMN2MEN1ALDH1A1HTT | |
| SCHEMBL4726429 | 0.75 | LMNA (0.51) | KMT2ASMN1; SMN2MEN1ALDH1A1HTT | |
| SCHEMBL8214695 | 0.74 | ALDH1A1 (0.40) | PDGFRBPDGFRAKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |