Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727043 | 0.89 | GFER (0.48) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL4729811 | 0.84 | ALDH1A1 (0.50) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL4779866 | 0.84 | DRD3 (0.49) | LMNAALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL4727067 | 0.83 | TP53 (0.44) | LMNAMAPTTP53THRB | |
| SCHEMBL4725295 | 0.82 | SMN1; SMN2 (0.55) | LMNAALDH1A1KMT2AMEN1TP53 | |
| SCHEMBL4727053 | 0.82 | LMNA (0.52) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL4726021 | 0.81 | LMNA (0.54) | LMNATP53HTTNPSR1 | |
| SCHEMBL4779869 | 0.81 | SMN1; SMN2 (0.51) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL4725768 | 0.81 | MAPT (0.51) | LMNAMAPTALDH1A1KMT2ATP53 | |
| SCHEMBL4726498 | 0.81 | ALDH1A1 (0.44) | LMNAMAPTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | claimed |
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | disclosed |