Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2094864 | 0.82 | ROCK2 (0.42) | BRD4NPC1PABPC1RAB9AL3MBTL1 | |
| SCHEMBL27666323 | 0.82 | CYP1A2 (0.47) | BRD4NPC1PABPC1RAB9AL3MBTL1 | |
| SCHEMBL1645759 | 0.77 | DRD2 (0.52) | NPC1RAB9ALMNASMN1; SMN2THRB | |
| SCHEMBL5537866 | 0.76 | L3MBTL1 (0.53) | NPC1PABPC1RAB9AL3MBTL1ROCK2 | |
| SCHEMBL4580694 | 0.75 | MAPT (0.44) | BRD4LMNAMAPK7 | |
| SCHEMBL4581221 | 0.75 | HSP90AA1 (0.56) | — | |
| SCHEMBL1471207 | 0.74 | USP2 (0.47) | BRD4NPC1PABPC1RAB9AL3MBTL1 | |
| SCHEMBL4117538 | 0.73 | ALDH1A1 (0.60) | BRD4NPC1RAB9AL3MBTL1 | |
| SCHEMBL5537861 | 0.73 | L3MBTL1 (0.53) | NPC1PABPC1RAB9AL3MBTL1ROCK2 | |
| SCHEMBL13813537 | 0.73 | LMNA (0.43) | L3MBTL1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024963-A1 | BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |