Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 12/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.41 |
| ▸ | TSHR | P16473 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL906377 | 0.78 | NQO2 (0.41) | HSD17B10KDM4ETSHRALDH1A1CYP1A2 | |
| SCHEMBL4727593 | 0.68 | KDM4E (0.41) | HSD17B10KDM4ETSHRALDH1A1CYP1A2 | |
| SCHEMBL3346362 | 0.67 | DHODH (0.39) | HSD17B10KDM4ETSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL3843553 | 0.66 | ERCC1 (0.43) | HSD17B10KDM4ETSHRALDH1A1CYP1A2 | |
| SCHEMBL17580228 | 0.63 | KDM4E (0.62) | HSD17B10KDM4ETSHRALDH1A1CYP1A2 | |
| SCHEMBL6119872 | 0.60 | HDAC3 (0.48) | HSD17B10KDM4ETSHRALDH1A1CYP1A2 | |
| SCHEMBL3714726 | 0.60 | ALDH1A1 (0.60) | KDM4EALDH1A1CYP1A2HPGDSMN1; SMN2 | |
| SCHEMBL31424794 | 0.59 | LMNA (0.42) | HPGD | |
| SCHEMBL16176491 | 0.59 | HTT (0.51) | TSHRSMN1; SMN2MAPT | |
| SCHEMBL30979352 | 0.58 | EGLN1 (0.45) | HSD17B10CYP1A2HPGDSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | disclosed |