Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.71 |
| ▸ | DRD2 | P14416 | 12/20 | 0.71 |
| ▸ | HTR2A | P28223 | 12/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.71 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.58 |
| ▸ | DRD1 | P21728 | 3/20 | 0.57 |
| ▸ | HTR2C | P28335 | 3/20 | 0.57 |
| ▸ | HTR3A | P46098 | 2/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725929 | 0.89 | DRD2 (0.73) | HTR1ADRD2HTR2AKCNH2ADRA1D | |
| SCHEMBL4725855 | 0.83 | DRD2 (1.00) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL4729511 | 0.82 | DRD2 (1.00) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL4727401 | 0.78 | DRD2 (0.90) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL4727331 | 0.78 | DRD2 (0.56) | HTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL9373235 | 0.77 | SIGMAR1 (0.63) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL8948107 | 0.76 | HTR1A (0.73) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL4892696 | 0.76 | HTR1A (0.64) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL7098475 | 0.75 | HTR1A (0.63) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL5763172 | 0.74 | HTR1A (0.60) | HTR1ADRD2HTR2AKCNH2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |