Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL29577271 | 0.94 | — | — | |
| Bicarbonate SCHEMBL6580033 | 0.94 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL2023098 | 0.94 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL6750021 | 0.94 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL9950130 | 0.94 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL7719205 | 0.94 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL29575457 | 0.94 | — | — | |
| Bicarbonate SCHEMBL10907035 | 0.94 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL6577630 | 0.94 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL138735 | 0.94 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 228 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113559884-A | Hydrogenation catalyst for sulfurized heavy oil and its preparing process and application | 中国石油化工股份有限公司 | 2021-10-29 | — | — | CN | claimed |
| CN-112735855-A | Alkaline nickel-cobalt carbonate and manganese dioxide core-shell structure supercapacitor composite electrode material loaded with foamed nickel and preparation method thereof | 吉林大学 | 2021-04-30 | — | — | CN | claimed |
| US-10788722-B2 | Electrochromic devices and method for forming such devices | CLEARIST INC. (US) | 2020-09-29 | — | — | US | claimed |
| US-20170075182-A1 | ELECTROCHROMIC DEVICES AND METHOD FOR FORMING SUCH DEVICES | CLEARIST INC. | 2017-03-16 | — | — | US | claimed |
| WO-2014119943-A1 | METHOD FOR FABRICATING LARGE METAL NANOFIBER ELECTRODE ARRAY USING ALIGNED METAL NANOFIBER | 포항공과대학교 산학협력단 (KR) | 2014-08-07 | — | — | WO | claimed |
| EP-1412284-A2 | COMPOSITION FOR TREATING CELLS AND METHODS FOR QUALITATIVELY AND QUANTITATIVELY CUSTOMIZING THE FORMULATION THEREOF FOR A HEURISTICALLY DERIVED LIVING CELL NUTRIENT-COMPOSITION-ON-DEMAND | Runkis, Walter H. (US) | 2004-04-28 | — | — | EP | claimed |
| CN-1125679-C | Hydrogenation catalyst and preparation method thereof | LOYNA WILK CO LTD (DE) | 2003-10-29 | — | — | CN | claimed |
| CN-1125678-C | functional group hydrogenation catalyst and preparation method thereof | LOYNA WILK CO LTD (DE) | 2003-10-29 | — | — | CN | claimed |
| US-20030073580-A1 | Composition for treating cells and method for qualitatively and quantitatively customizing the formulation thereof | RUNKIS WALTER H (US) | 2003-04-17 | — | — | US | claimed |
| US-6508995-B1 | Reducing melting temperature by formation of copper, nickel or zinc diamine complex optionally with water inclusion | FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) | 2003-01-21 | — | — | US | claimed |
| WO-2002100772-A2 | COMPOSITION AND METHOD FOR TREATING CELLS AND PLANTS | RUNKIS WALTER H (US) | 2002-12-19 | — | — | WO | claimed |
| CN-1349433-A | Nickel catalyst for hydrogenating functional groups and method for producing same | LOYNA WILK CO LTD (DE) | 2002-05-15 | — | — | CN | claimed |
| CN-1349434-A | Hydrogenating catalyst and method for producing the same | LOYAN WILK CO LTD (DE) | 2002-05-15 | — | — | CN | claimed |
| EP-0114704-B2 | Nickel-based catalyst, its preparation and its application | UNILEVER NV (NL) | 1995-01-04 | — | — | EP | claimed |
| US-4670416-A | RAPID PRECIPITATION; SILICA | INTERNATIONALE OCTROOI MAATSCHAPPIJ"OCTROPA"B.V. (NL) | 1987-06-02 | — | — | US | claimed |
| EP-0114704-B1 | NICKEL-BASED CATALYST, ITS PREPARATION AND ITS APPLICATION | UNILEVER N.V. (NL) | 1986-07-02 | — | — | EP | claimed |
| EP-0114704-A2 | Nickel-based catalyst, its preparation and its application | UNILEVER N.V. (NL) | 1984-08-01 | — | — | EP | claimed |
| US-4371573-A | Electroless deposition of nickel coatings and depositing baths therefor | SIEMENS AKTIENGESELLSCHAFT (DE) | 1983-02-01 | — | — | US | claimed |
| US-20260125603-A1 | ISOMERIZATION OF BIOFEEDS OVER BASE METAL CATALYSTS | EXXONMOBIL TECHNOLOGY AND ENGINEERING CO (US) | 2026-05-07 | — | — | US | disclosed |
| US-4371573-A | Electroless deposition of nickel coatings and depositing baths therefor | SIEMENS AKTIENGESELLSCHAFT (DE) | 1983-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125603-A1 | ISOMERIZATION OF BIOFEEDS OVER BASE METAL CATALYSTS | CYP4F8, SLC6A12, DBF4 | CA4 78/4885CA1 109/4885FAHD1 1683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.