Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.45 |
| ▸ | FRK | P42685 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EIF4E | P06730 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725920 | 0.89 | EGLN1 (0.48) | MAPK14CYP2C9ATMHPGDHTT | |
| SCHEMBL4728221 | 0.84 | HPGD (0.48) | MAPK14CYP2C9HPGDKMT2AMEN1 | |
| SCHEMBL4728365 | 0.83 | RAF1 (0.41) | RAF1BRAF | |
| SCHEMBL4729210 | 0.82 | TRPV1 (0.42) | MAPK14EPHA3FRKRAF1BRAF | |
| SCHEMBL4728308 | 0.81 | EGLN1 (0.48) | ATMHPGDHTTTAAR1KMT2A | |
| SCHEMBL4781066 | 0.80 | MAPK14 (0.55) | MAPK14EPHA3FRKRAF1 | |
| SCHEMBL4781803 | 0.79 | MAPK14 (0.50) | MAPK14CYP2C9RAF1BRAF | |
| SCHEMBL4730164 | 0.77 | MAPK14 (0.53) | MAPK14CYP2C9EPHA3FRKRAF1 | |
| SCHEMBL4784220 | 0.77 | MAPK14 (0.42) | MAPK14EPHA3FRKRAF1BRAF | |
| SCHEMBL4727468 | 0.77 | MAPK14 (0.47) | MAPK14EPHA3FRKRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |