Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.48 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725920 | 0.91 | EGLN1 (0.48) | EGLN1NAMPTTAAR1HPGDKMT2A | |
| SCHEMBL4728367 | 0.81 | MAPK14 (0.50) | TAAR1HPGDKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4782957 | 0.80 | BRAF (0.42) | EGLN1NAMPTHPGDKMT2AALDH1A1 | |
| SCHEMBL5593020 | 0.80 | RAB9A (0.49) | NAMPTTAAR1HPGDKMT2AALDH1A1 | |
| SCHEMBL4727468 | 0.79 | MAPK14 (0.47) | EGLN1NAMPT | |
| SCHEMBL4410203 | 0.79 | HCAR3 (0.44) | NAMPTKMT2AALDH1A1SMN1; SMN2ROCK2 | |
| SCHEMBL4725917 | 0.77 | RAF1 (0.44) | — | |
| SCHEMBL4728099 | 0.76 | RAF1 (0.41) | EGLN1 | |
| SCHEMBL4729070 | 0.75 | IKBKB (0.43) | EGLN1KMT2AALDH1A1SMN1; SMN2ROCK2 | |
| SCHEMBL4726798 | 0.74 | RAF1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |