Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3075680 | 0.81 | LTA4H (0.46) | PPARAPPARDPLA2G7KDM4ESMN1; SMN2 | |
| SCHEMBL3562321 | 0.81 | SMN1; SMN2 (0.46) | PPARAPPARDSMN1; SMN2PPARG | |
| SCHEMBL3069744 | 0.80 | LMNA (0.42) | MAPK1KDM4ESMN1; SMN2NR4A2MAOB | |
| SCHEMBL3082749 | 0.80 | NR1I2 (0.43) | PLA2G7MAOBLSSALDH1A1 | |
| SCHEMBL3087766 | 0.78 | HRH2 (0.44) | SMN1; SMN2HRH2HRH1MAOB | |
| SCHEMBL4728801 | 0.77 | FFAR4 (0.34) | PPARAPLA2G7SMN1; SMN2PPARGALDH1A1 | |
| SCHEMBL3078338 | 0.76 | PLA2G7 (0.39) | MAPK1PLA2G7SMN1; SMN2LSSALDH1A1 | |
| SCHEMBL3074106 | 0.74 | BCL2L1 (0.49) | KDM4ESMN1; SMN2NR4A2ALDH1A1 | |
| SCHEMBL3135618 | 0.74 | ESR1 (0.54) | KDM4EMAOBALDH1A1 | |
| SCHEMBL4617631 | 0.73 | BCL9 (0.44) | KDM4ESMN1; SMN2FAAHHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891026-A2 | CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | Smithkline Beecham Corporation (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006127871-A2 | CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-30 | — | — | WO | disclosed |