Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.65 |
| ▸ | DRD2 | P14416 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.65 |
| ▸ | HTR1A | P08908 | 4/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.65 |
| ▸ | HTR2A | P28223 | 4/20 | 0.65 |
| ▸ | HTR2C | P28335 | 4/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.65 |
| ▸ | HRH1 | P35367 | 4/20 | 0.65 |
| ▸ | DRD3 | P35462 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11168758 | 0.87 | KDM1A (0.65) | MAPTCYP2D6DRD2LMNASMN1; SMN2 | |
| SCHEMBL4783514 | 0.81 | KDM1A (0.45) | MAPTCYP2D6DRD2LMNASMN1; SMN2 | |
| SCHEMBL14292497 | 0.80 | LMNA (0.72) | MAPTCYP2D6DRD2LMNASMN1; SMN2 | |
| Prochlorperazine SCHEMBL29369439 | 0.79 | DRD2 (1.00) | MAPTCYP2D6DRD2LMNASMN1; SMN2 | |
| Prochlorperazine SCHEMBL29358207 | 0.79 | DRD2 (1.00) | MAPTCYP2D6DRD2LMNASMN1; SMN2 | |
| Prochlorperazine SCHEMBL14126977 | 0.79 | DRD2 (1.00) | MAPTCYP2D6DRD2LMNASMN1; SMN2 | |
| Prochlorperazine SCHEMBL18429 | 0.79 | DRD2 (1.00) | MAPTCYP2D6DRD2LMNASMN1; SMN2 | |
| Prochlorperazine SCHEMBL1041250 | 0.78 | DRD2 (0.98) | MAPTCYP2D6DRD2LMNASMN1; SMN2 | |
| Prochlorperazine SCHEMBL2506559 | 0.78 | DRD2 (0.98) | MAPTCYP2D6DRD2LMNASMN1; SMN2 | |
| SCHEMBL21436146 | 0.78 | KDM1A (0.79) | MAPTCYP2D6DRD2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021745-A2 | HEPATITIS C VIRUS ENTRY INHIBITORS | ITHERX PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |