Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11142380 | 0.89 | NPC1 (0.54) | NPC1L3MBTL1AKR1C3MEN1KMT2A | |
| SCHEMBL3951056 | 0.87 | NPC1 (0.53) | NPC1L3MBTL1AKR1C3MEN1KMT2A | |
| SCHEMBL6265387 | 0.84 | NPC1 (0.50) | NPC1L3MBTL1AKR1C3MEN1KMT2A | |
| SCHEMBL15539286 | 0.82 | MTNR1A (0.48) | NPC1L3MBTL1AKR1C3MEN1KMT2A | |
| SCHEMBL3912820 | 0.79 | AKR1C3 (0.55) | AKR1C3MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL9393440 | 0.77 | MEN1 (0.44) | NPC1L3MBTL1AKR1C3MEN1KMT2A | |
| SCHEMBL629143 | 0.76 | ALDH1A1 (0.52) | NPC1L3MBTL1AKR1C3MEN1KMT2A | |
| SCHEMBL11160065 | 0.76 | AKR1C3 (0.57) | NPC1AKR1C3MEN1KMT2ACYP3A4 | |
| SCHEMBL12411254 | 0.75 | NPC1 (0.50) | NPC1L3MBTL1AKR1C3MEN1KMT2A | |
| SCHEMBL168235 | 0.75 | NPC1 (0.50) | NPC1L3MBTL1AKR1C3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033466-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | COMBINATORX (SINGAPORE) PRE. LTD. (SG) | 2008-03-20 | — | — | WO | disclosed |
| EP-0351856-A2 | Thiazolo[5,4-b]azepine compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |