SCHEMBL4729448

SCHEMBL4729448

COc1c(F)ccc(S(=O)(=O)Cl)c1C#N

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 3/20 0.41
ACLY P53396 1/20 0.39
EPAS1 Q99814 15/20 0.39
SLC22A12 Q96S37 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL175274 0.81 SMN1; SMN2 (0.41) TRPV4ACLYSLC22A12
SCHEMBL29518830 0.77 SLC6A3 (0.36) TRPV4
SCHEMBL186103 0.77 SLC6A3 (0.36) TRPV4
SCHEMBL15189949 0.75 TRPV4 (0.47) TRPV4ACLY
SCHEMBL31566968 0.73 TRPV4 (0.50) TRPV4ACLY
SCHEMBL25203921 0.71 EPAS1 (0.38) TRPV4EPAS1
SCHEMBL970204 0.71 TRPV4 (0.42) TRPV4EPAS1SLC22A12
SCHEMBL18919971 0.71 TRPV4 (0.40) TRPV4
SCHEMBL3247679 0.71 NPC1 (0.49) TRPV4EPAS1SLC22A12
SCHEMBL29700040 0.71 TRPV4 (0.41) TRPV4ACLY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008031712-A2 PESTICIDAL ACTIVE MIXTURES COMPRISING SULFONAMIDES BASF SE (DE) 2008-03-20 WO disclosed