Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI1 | Q9ULC6 | 4/20 | 1.00 |
| ▸ | PADI3 | Q9ULW8 | 4/20 | 1.00 |
| ▸ | PADI4 | Q9UM07 | 4/20 | 1.00 |
| ▸ | PADI2 | Q9Y2J8 | 4/20 | 1.00 |
| ▸ | TGM2 | P21980 | 1/20 | 1.00 |
| ▸ | S100A4 | P26447 | 7/20 | 0.74 |
| ▸ | NSD2 | O96028 | 4/20 | 0.69 |
| ▸ | TDP2 | O95551 | 3/20 | 0.69 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CDC25B | P30305 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599216 | 0.85 | S100A4 (1.00) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL459004 | 0.81 | NSD2 (1.00) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL12760676 | 0.78 | PADI1 (0.64) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL21801777 | 0.78 | PADI1 (0.64) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL29548274 | 0.78 | S100A4 (0.65) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL10507042 | 0.78 | S100A4 (0.65) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL15552423 | 0.78 | PADI1 (0.64) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL5915065 | 0.75 | TDP2 (0.81) | PADI1PADI3PADI4PADI2TGM2 | |
| Phanquone SCHEMBL7633567 | 0.75 | MEN1 (1.00) | PADI1PADI3PADI4PADI2TGM2 | |
| Phanquone SCHEMBL30956643 | 0.75 | MEN1 (1.00) | PADI1PADI3PADI4PADI2TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170128483-A1 | HOST DEPENDENCY FACTORS AS TARGETS FOR ANTIVIRAL THERAPY | RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG (DE) | 2017-05-11 | — | — | US | disclosed |
| US-9522908-B2 | Ezrin inhibitors and methods of making and using | Gerogetown University (US) | 2016-12-20 | — | — | US | disclosed |
| WO-2015144688-A1 | HOST DEPENDENCY FACTORS AS TARGETS FOR ANTIVIRAL THERAPY | Ruprecht-Karls-Universität Heidelberg (DE) | 2015-10-01 | — | — | WO | disclosed |
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| WO-2012064396-A9 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2012-07-05 | — | — | WO | disclosed |
| WO-2012064396-A2 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2012-05-18 | — | — | WO | disclosed |
| CN-101685733-A | High-temperature thermal fuse device | THERM O DISC INC | 2010-03-31 | — | — | CN | disclosed |
| WO-2008063662-A2 | GOLD (III) CHLORIDE COMPOSITIONS FOR CANCER | BLACK LION PHARMACEUTICALS (US) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | EZR, NHERF1, ERMP1 | PADI1 1715/4885PADI3 2023/4885PADI4 2045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.