Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.34 |
| ▸ | PTPRF | P10586 | 5/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730121 | 0.86 | P2RY12 (0.37) | P2RY12PTPN1PTPRFPTPN2MAPT | |
| SCHEMBL5197708 | 0.74 | CYP2C19 (0.42) | PTPN1MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL4728145 | 0.74 | PPARG (0.47) | PTPN1GAA | |
| SCHEMBL14260755 | 0.74 | PPARG (0.47) | PTPN1GAA | |
| SCHEMBL5199597 | 0.69 | ALOX5 (0.38) | P2RY12PTPN1 | |
| SCHEMBL5197702 | 0.69 | PTPN1 (0.39) | PTPN1MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL14260809 | 0.69 | PPARG (0.44) | — | |
| SCHEMBL4730467 | 0.69 | PPARG (0.44) | — | |
| SCHEMBL4731059 | 0.68 | PPARG (0.36) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL4730478 | 0.68 | GAA (0.41) | PTPN1PTPRFPTPN2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033934-A1 | SUBSTITUTED HETEROARYL CARBOXYLIC ACID DERIVATIVES AS PTB-1B INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |