Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 5/20 | 0.35 |
| ▸ | BRD2 | P25440 | 4/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PKLR | P30613 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732276 | 0.85 | CNR2 (0.41) | TP53MAPTMKNK2 | |
| SCHEMBL4733516 | 0.85 | USP30 (0.37) | USP30BRD4BRD2BRD3TP53 | |
| SCHEMBL4733368 | 0.84 | CHRM2 (0.41) | BRD4MAPTOPRL1MKNK2PIK3CD | |
| SCHEMBL4734091 | 0.77 | MAOA (0.33) | — | |
| SCHEMBL4781177 | 0.74 | KMT2A (0.49) | BRD4BRD2BRD3TP53LMNA | |
| SCHEMBL4732698 | 0.73 | GSTO1 (0.38) | USP30LMNAOPRL1 | |
| SCHEMBL4730716 | 0.73 | SLC2A1 (0.45) | TP53PKMTSHR | |
| SCHEMBL4731657 | 0.73 | HTR1A (0.38) | USP30 | |
| SCHEMBL4733893 | 0.73 | KDM4E (0.38) | HTTBRD4BRD2BRD3TP53 | |
| SCHEMBL6103336 | 0.73 | HTT (0.43) | USP30HTTBRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |