Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730340 | 0.93 | HPGD (0.41) | SMN1; SMN2LMNAALDH1A1KMT2APOLB | |
| SCHEMBL8221280 | 0.86 | MEN1 (0.33) | SMN1; SMN2LMNAALDH1A1KMT2APOLB | |
| SCHEMBL4729596 | 0.81 | PDGFRB (0.50) | SMN1; SMN2LMNAALDH1A1KMT2APOLB | |
| SCHEMBL5511163 | 0.80 | RAB9A (0.60) | SMN1; SMN2LMNAALDH1A1KMT2APOLB | |
| SCHEMBL8214243 | 0.80 | HPGD (0.33) | SMN1; SMN2LMNAALDH1A1KMT2APOLB | |
| SCHEMBL5503643 | 0.78 | KDM4E (0.59) | SMN1; SMN2LMNAALDH1A1KMT2APOLB | |
| SCHEMBL4731550 | 0.78 | ALDH1A1 (0.47) | SMN1; SMN2LMNAALDH1A1KMT2APOLB | |
| SCHEMBL4728657 | 0.77 | HPGDS (0.46) | SMN1; SMN2LMNAALDH1A1KMT2APOLB | |
| SCHEMBL4731779 | 0.73 | GRM1 (0.51) | SMN1; SMN2LMNAALDH1A1KMT2APOLB | |
| SCHEMBL4730657 | 0.73 | MAPT (0.35) | SMN1; SMN2LMNAALDH1A1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |