Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730782 | 0.92 | IRAK4 (0.36) | IRAK4GPBAR1APOBEC3AAPOBEC3GHPGD | |
| SCHEMBL4730432 | 0.81 | NPC1 (0.38) | IRAK4L3MBTL1NPC1SLC6A9 | |
| SCHEMBL14223294 | 0.80 | NPC1 (0.37) | IRAK4L3MBTL1NPC1HPGDSLC6A9 | |
| SCHEMBL4731095 | 0.73 | S1PR1 (0.36) | IRAK4L3MBTL1NPC1 | |
| SCHEMBL14223018 | 0.72 | KDM4E (0.37) | IRAK4L3MBTL1NPC1HPGD | |
| SCHEMBL4728477 | 0.70 | SLC6A9 (0.35) | IRAK4JAK2SLC6A9 | |
| SCHEMBL4730446 | 0.67 | KDM4E (0.38) | NPC1 | |
| SCHEMBL4798458 | 0.66 | APOBEC3A (0.33) | GPBAR1APOBEC3AAPOBEC3G | |
| SCHEMBL4730991 | 0.66 | APOBEC3A (0.33) | NPC1APOBEC3AAPOBEC3GJAK2HPGD | |
| SCHEMBL5311722 | 0.64 | HPGD (0.34) | L3MBTL1NPC1APOBEC3AAPOBEC3GHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |