Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735468 | 0.99 | LMNA (0.32) | LMNACYP2C9ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL4732278 | 0.82 | ALDH1A1 (0.33) | ALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL4730924 | 0.79 | ALDH1A1 (0.32) | ALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL4735483 | 0.78 | BRD4 (0.41) | LMNA | |
| SCHEMBL4734831 | 0.78 | PARG (0.36) | TDP1 | |
| SCHEMBL4732186 | 0.78 | HTT (0.36) | LMNAALDH1A1 | |
| SCHEMBL4919374 | 0.78 | HTT (0.36) | LMNA | |
| SCHEMBL4732586 | 0.77 | HTT (0.38) | LMNAALDH1A1 | |
| SCHEMBL4799653 | 0.77 | PARG (0.35) | TDP1 | |
| SCHEMBL4801590 | 0.77 | HTT (0.38) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |