SCHEMBL4736140 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	SFRP1	Q8N474	2/20	0.42

▸	DPP4	P27487	6/20	0.36

▸	DPP7	Q9UHL4	4/20	0.36

▸	KCNH2	Q12809	4/20	0.36

▸	HTR1A	P08908	2/20	0.35

▸	HTR7	P34969	2/20	0.35

▸	DRD2	P14416	1/20	0.35

▸	HTR6	P50406	1/20	0.35

▸	DPP8	Q6V1X1	3/20	0.35

▸	DPP9	Q86TI2	3/20	0.35

▸	EPHX2	P34913	1/20	0.35

▸	ALDH1A1	P00352	1/20	0.34

▸	POLB	P06746	1/20	0.34

▸	SMN1; SMN2	Q16637	1/20	0.34

▸	L3MBTL1	Q9Y468	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4736144	0.93	SFRP1 (0.42)	SFRP1DPP4DPP7KCNH2HTR1A
SCHEMBL4731040	0.93	SFRP1 (0.42)	SFRP1DPP4DPP7KCNH2HTR1A
SCHEMBL4730501	0.86	DPP4 (0.39)	SFRP1DPP4DPP7KCNH2DPP8
SCHEMBL4731048	0.86	SFRP1 (0.42)	SFRP1DPP4DPP7KCNH2HTR1A
SCHEMBL4735151	0.82	BRD4 (0.35)	SFRP1DPP4DPP7KCNH2HTR6
SCHEMBL4734135	0.80	SFRP1 (0.50)	SFRP1EPHX2ALDH1A1POLBSMN1; SMN2
SCHEMBL4730846	0.80	DPP4 (0.39)	SFRP1DPP4DPP7KCNH2DPP8
SCHEMBL4733107	0.75	SFRP1 (0.43)	SFRP1
SCHEMBL4734751	0.73	SFRP1 (0.50)	SFRP1EPHX2ALDH1A1POLBSMN1; SMN2
SCHEMBL4735477	0.73	DPP4 (0.36)	SFRP1DPP4DPP7KCNH2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2008061029-A1	ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE	WYETH (US)	2008-05-22	—	—	WO	disclosed