Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | BRD2 | P25440 | 2/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.35 |
| ▸ | WNT3 | P56703 | 1/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733825 | 0.87 | SFRP1 (0.46) | BRD4BRD2BRD3WNT3SFRP1 | |
| SCHEMBL4732377 | 0.86 | WNT3 (0.34) | BRD4BRD2BRD3WNT3SFRP1 | |
| SCHEMBL4730501 | 0.84 | DPP4 (0.39) | SFRP1ACLYHDAC8ALDH1A1L3MBTL1 | |
| SCHEMBL4732376 | 0.84 | WNT3 (0.36) | BRD4BRD2BRD3WNT3SFRP1 | |
| SCHEMBL4797961 | 0.84 | BRD4 (0.36) | BRD4BRD2BRD3WNT3SFRP1 | |
| SCHEMBL4730634 | 0.83 | WNT3 (0.37) | BRD4BRD2BRD3WNT3SFRP1 | |
| SCHEMBL4797958 | 0.82 | DRD2 (0.38) | BRD4BRD2BRD3WNT3SFRP1 | |
| SCHEMBL4731040 | 0.82 | SFRP1 (0.42) | SFRP1ALDH1A1L3MBTL1DPP4KCNH2 | |
| SCHEMBL4736140 | 0.82 | SFRP1 (0.42) | SFRP1ALDH1A1L3MBTL1DPP4KCNH2 | |
| SCHEMBL4734135 | 0.78 | SFRP1 (0.50) | SFRP1ALDH1A1L3MBTL1CNR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |