Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 3/20 | 0.63 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.48 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.48 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735697 | 0.88 | LMNA (0.51) | FASNHSD11B1LMNAALDH1A1MAPT | |
| SCHEMBL4733674 | 0.88 | ALDH1A1 (0.52) | FASNLMNAALDH1A1MEN1MAPT | |
| SCHEMBL14209216 | 0.88 | ALDH1A1 (0.52) | FASNLMNAALDH1A1HPGD | |
| SCHEMBL4175647 | 0.87 | PARP10 (0.56) | FASNLMNAALDH1A1PARP10PARP14 | |
| SCHEMBL14210111 | 0.86 | FASN (0.48) | FASNHSD11B1LMNAALDH1A1POLB | |
| SCHEMBL4796218 | 0.86 | FASN (0.54) | FASNHSD11B1LMNAALDH1A1POLB | |
| SCHEMBL16799271 | 0.86 | HPGD (0.50) | FASNLMNAALDH1A1HPGD | |
| SCHEMBL4191753 | 0.86 | PARP10 (0.58) | FASNHSD11B1LMNAALDH1A1MEN1 | |
| SCHEMBL4197739 | 0.86 | FASN (0.61) | FASNALDH1A1MAPTHPGD | |
| SCHEMBL4735211 | 0.85 | CA12 (0.58) | FASNHSD11B1LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059214-A1 | BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | WO | disclosed |