Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.39 |
| ▸ | CETP | P11597 | 15/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731307 | 0.85 | CETP (0.44) | CETPTACR1 | |
| SCHEMBL4731680 | 0.83 | CETP (0.43) | CETPTACR1 | |
| SCHEMBL4732423 | 0.83 | CETP (0.41) | CETPTACR1 | |
| SCHEMBL4731216 | 0.82 | CCR2 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4731354 | 0.80 | TACR1 (0.40) | TACR1GPBAR1 | |
| SCHEMBL4731791 | 0.79 | CETP (0.40) | CETPTACR1 | |
| SCHEMBL4728785 | 0.79 | TMEM97 (0.41) | CETPTACR1 | |
| SCHEMBL4728949 | 0.79 | TACR1 (0.35) | CETPTACR1 | |
| SCHEMBL4731447 | 0.78 | PTGDR2 (0.42) | TACR1 | |
| SCHEMBL3998806 | 0.75 | TACR1 (0.34) | CETPTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045564-A2 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2008-04-17 | — | — | WO | disclosed |