Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732619 | 0.91 | TAAR1 (0.43) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL4734133 | 0.90 | TBXAS1 (0.40) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4730493 | 0.86 | ALDH1A1 (0.40) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL4733242 | 0.85 | TDP1 (0.42) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL4731644 | 0.85 | ACHE (0.44) | ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL4731516 | 0.85 | MEN1 (0.39) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL4730979 | 0.84 | TBXAS1 (0.42) | ALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL4734310 | 0.84 | AKR1C3 (0.38) | ALDH1A1LMNASMN1; SMN2TSHRTP53 | |
| SCHEMBL4730503 | 0.81 | SMN1; SMN2 (0.47) | ALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL4731425 | 0.79 | KMT2A (0.40) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |