Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732619 | 0.94 | TAAR1 (0.43) | ALDH1A1POLBTAAR1TP53SMN1; SMN2 | |
| SCHEMBL4730503 | 0.89 | SMN1; SMN2 (0.47) | ALDH1A1POLBBRD4SMN1; SMN2KMT2A | |
| SCHEMBL4734310 | 0.85 | AKR1C3 (0.38) | ALDH1A1POLBTAAR1TP53GAA | |
| SCHEMBL4732031 | 0.85 | ALDH1A1 (0.41) | TDP1ALDH1A1TP53SMN1; SMN2KMT2A | |
| SCHEMBL4731425 | 0.85 | KMT2A (0.40) | TDP1ALDH1A1SMN1; SMN2KMT2AHTT | |
| SCHEMBL4734133 | 0.84 | TBXAS1 (0.40) | ALDH1A1POLBGAASMN1; SMN2KMT2A | |
| SCHEMBL4731644 | 0.83 | ACHE (0.44) | TDP1ALDH1A1HTTKDM4ELMNA | |
| SCHEMBL4733955 | 0.81 | CYP3A4 (0.46) | TDP1POLBKMT2ANPSR1CYP3A4 | |
| SCHEMBL4729817 | 0.79 | TSHR (0.43) | ALDH1A1SMN1; SMN2KMT2ACYP3A4MAPK1 | |
| SCHEMBL4732339 | 0.79 | NAMPT (0.38) | NAMPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |