Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.36 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732619 | 0.90 | TAAR1 (0.43) | SMN1; SMN2KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL4733242 | 0.89 | TDP1 (0.42) | SMN1; SMN2KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL4731425 | 0.84 | KMT2A (0.40) | SMN1; SMN2KMT2ALMNAALDH1A1 | |
| SCHEMBL4734310 | 0.83 | AKR1C3 (0.38) | SMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL4734133 | 0.82 | TBXAS1 (0.40) | SMN1; SMN2KMT2APOLBALDH1A1 | |
| SCHEMBL4732031 | 0.81 | ALDH1A1 (0.41) | SMN1; SMN2KMT2ALMNAALDH1A1 | |
| SCHEMBL4733452 | 0.81 | CNR2 (0.39) | KMT2A | |
| SCHEMBL4731644 | 0.81 | ACHE (0.44) | LMNAALDH1A1ACHE | |
| SCHEMBL4736402 | 0.80 | HTR1A (0.38) | KMT2A | |
| SCHEMBL4732339 | 0.80 | NAMPT (0.38) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |