Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731034 | 0.93 | POLB (0.37) | POLBTSHRTBXAS1ALDH1A1PRMT5 | |
| SCHEMBL4732951 | 0.88 | ALDH1A1 (0.41) | POLBTSHRTBXAS1ALDH1A1PRMT5 | |
| SCHEMBL4733942 | 0.85 | POLB (0.48) | POLBTSHRTBXAS1ALDH1A1PRMT5 | |
| SCHEMBL4796983 | 0.83 | SMN1; SMN2 (0.38) | POLBTSHRTBXAS1ALDH1A1PRMT5 | |
| SCHEMBL4734599 | 0.79 | POLB (0.48) | POLBTSHRTBXAS1ALDH1A1PRMT5 | |
| SCHEMBL4734886 | 0.76 | POLB (0.45) | POLBTSHRTBXAS1ALDH1A1PRMT5 | |
| SCHEMBL4733104 | 0.75 | POLB (0.42) | POLBTSHRTBXAS1ALDH1A1PRMT5 | |
| SCHEMBL4732136 | 0.74 | MEN1 (0.47) | POLBTSHRALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4782445 | 0.74 | TSHR (0.43) | TSHRTBXAS1L3MBTL1 | |
| SCHEMBL4733822 | 0.74 | SFRP1 (0.50) | POLBALDH1A1HTTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |