Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 6/20 | 0.50 |
| ▸ | CCR8 | P51685 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 2/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | WNT3 | P56703 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735919 | 0.92 | MCHR1 (0.51) | SFRP1CCR8STSUSP30KDM4E | |
| SCHEMBL16013308 | 0.89 | STS (0.61) | SFRP1CCR8STSUSP30KDM4E | |
| SCHEMBL4732954 | 0.88 | ALPL (0.49) | SFRP1CCR8KDM4EHSD17B10ALPL | |
| SCHEMBL4735664 | 0.84 | SFRP1 (0.58) | SFRP1CCR8STSUSP30KDM4E | |
| SCHEMBL8009703 | 0.83 | STS (0.56) | SFRP1CCR8STSUSP30BRD4 | |
| SCHEMBL17394215 | 0.83 | STS (0.53) | SFRP1CCR8STSUSP30KDM4E | |
| SCHEMBL16124960 | 0.80 | CCR8 (0.52) | SFRP1CCR8STSUSP30KDM4E | |
| SCHEMBL21760965 | 0.80 | MCHR1 (0.51) | ALPLLMNA | |
| SCHEMBL21760943 | 0.80 | MCHR1 (0.51) | ALPLLMNA | |
| SCHEMBL3413300 | 0.80 | STS (0.57) | SFRP1CCR8STSBRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |