Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.58 |
| ▸ | CCR8 | P51685 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | SFRP1 | Q8N474 | 4/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340628 | 0.88 | CCR8 (0.66) | CCR8BRD4SFRP1 | |
| SCHEMBL1339728 | 0.84 | CCR8 (0.52) | NR1H2CCR8BRD4SFRP1GPR119 | |
| SCHEMBL4734261 | 0.84 | HRH2 (0.51) | NR1H2CCR8SFRP1DRD2ADRA1D | |
| SCHEMBL15932397 | 0.83 | CCR8 (0.60) | CCR8BRD4SFRP1GPR119STS | |
| SCHEMBL31234649 | 0.83 | CCR8 (0.60) | CCR8BRD4SFRP1GPR119STS | |
| SCHEMBL4784120 | 0.82 | GPR119 (0.56) | NR1H2CCR8BRD4SFRP1GPR119 | |
| SCHEMBL4736604 | 0.81 | SFRP1 (0.67) | NR1H2CCR8BRD4SFRP1STS | |
| SCHEMBL377863 | 0.81 | ALDH1A1 (0.55) | CCR8BRD4GPR119STSALDH1A1 | |
| SCHEMBL31234802 | 0.80 | MEN1 (0.60) | CCR8BRD4SFRP1DRD2ADRA1D | |
| SCHEMBL2107778 | 0.80 | MEN1 (0.60) | CCR8BRD4SFRP1DRD2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |