Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 4/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | GALR1 | P47211 | 1/20 | 0.30 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730920 | 0.85 | GPR3 (0.39) | GPR3VEGFAPTGDR2TRPV4SCN8A | |
| SCHEMBL4732090 | 0.75 | AGBL2 (0.34) | — | |
| SCHEMBL4733537 | 0.74 | GPR3 (0.40) | GPR3CES1ABL1TRPV4SLC40A1 | |
| SCHEMBL4730728 | 0.73 | BACE1 (0.35) | — | |
| SCHEMBL4733059 | 0.67 | TRPV4 (0.33) | TRPV4 | |
| SCHEMBL4782389 | 0.66 | ATM (0.41) | — | |
| SCHEMBL4734722 | 0.64 | HCAR3 (0.33) | — | |
| SCHEMBL4733543 | 0.63 | GPR3 (0.40) | GPR3PTGDR2CES1TRPV4CTSL | |
| SCHEMBL31536406 | 0.62 | BACE1 (0.37) | CES1SLC40A1CTSLHSPA9 | |
| SCHEMBL2264074 | 0.62 | CES1 (0.51) | CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |