Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13468496 | 0.85 | ALDH1A1 (0.56) | MAPTALDH1A1L3MBTL1KMT2ALMNA | |
| SCHEMBL2405887 | 0.83 | CCR8 (0.53) | ALDH1A1HRH2HRH1NR1H2CCR8 | |
| SCHEMBL2405883 | 0.83 | CCR8 (0.53) | ALDH1A1HRH2HRH1NR1H2CCR8 | |
| SCHEMBL16219423 | 0.82 | CTSB (0.55) | HTR1AHTR7HTTRECQLUSP30 | |
| SCHEMBL4736968 | 0.81 | CCR8 (0.52) | CCR8 | |
| SCHEMBL128275 | 0.80 | ALDH1A1 (0.64) | MAPTALDH1A1L3MBTL1KMT2ALMNA | |
| SCHEMBL4781795 | 0.80 | ALDH1A1 (0.52) | MAPTALDH1A1L3MBTL1HTR1AHTR7 | |
| SCHEMBL4617865 | 0.78 | SFRP1 (0.51) | KMT2AMEN1 | |
| SCHEMBL13162704 | 0.78 | PKM (0.51) | MAPTALDH1A1L3MBTL1CCR8KMT2A | |
| SCHEMBL4623414 | 0.78 | BRD4 (0.55) | MAPTALDH1A1L3MBTL1CCR8KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |