SCHEMBL4735173

SCHEMBL4735173

CS(=O)(=O)Oc1cccc(C2(Cc3cccc(Br)c3)NC(=S)NC2=O)c1

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
MMP8 P22894 1/20 0.33
MMP14 P50281 1/20 0.33
MAOB P27338 5/20 0.32
MAOA P21397 2/20 0.32
ADAM17 P78536 1/20 0.32
TP53 P04637 2/20 0.32
MDM2 Q00987 2/20 0.32
IDO1 P14902 1/20 0.31
AGXT P21549 1/20 0.31
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5067169 0.91 MMP8 (0.33) CA2RXFP1MMP8MMP14MAOB
SCHEMBL5066412 0.91 MAOB (0.35) CA2RXFP1MAOBMAOAADAM17
SCHEMBL5066447 0.89 MMP8 (0.32) CA2RXFP1MMP8MMP14MAOB
SCHEMBL5066207 0.88 MMP8 (0.31) MMP8MMP14MAOBMAOAADAM17
SCHEMBL5066553 0.88 TP53 (0.32) CA2RXFP1MMP8MMP14MAOB
SCHEMBL4733752 0.86 ADAM17 (0.32) CA2MMP8MMP14ADAM17TP53
SCHEMBL5066481 0.86 MAOB (0.32) MAOBMAOA
SCHEMBL5069132 0.85 CA2 (0.40) CA2ADAM17TP53MDM2
SCHEMBL5066554 0.82 L3MBTL1 (0.35) MAOBMAOATP53
SCHEMBL5066597 0.79 MAOB (0.33) CA2MMP14MAOBMAOAADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1979324-A2 NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER'S DISEASE, NEURODEGENERATION AND DEMENTIA Astra Zeneca AB (SE) 2008-10-15 EP claimed
WO-2007058602-A2 NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA. ASTRAZENECA AB (SE) 2007-05-24 WO claimed
EP-1979324-A2 NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER'S DISEASE, NEURODEGENERATION AND DEMENTIA Astra Zeneca AB (SE) 2008-10-15 EP disclosed
WO-2008076046-A1 NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES ASTRAZENECA AB (SE) 2008-06-26 WO disclosed
WO-2007058602-A2 NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA. ASTRAZENECA AB (SE) 2007-05-24 WO disclosed