Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734993 | 0.89 | CA2 (0.33) | ADAM17CA2 | |
| SCHEMBL4735347 | 0.89 | ADAM17 (0.30) | ADAM17 | |
| SCHEMBL4737598 | 0.88 | ADAM17 (0.35) | ADAM17MMP8MMP14 | |
| SCHEMBL4735173 | 0.86 | CA2 (0.33) | ADAM17CA2MMP8MMP14TP53 | |
| SCHEMBL4736892 | 0.83 | CA2 (0.32) | CA2 | |
| SCHEMBL5069132 | 0.80 | CA2 (0.40) | ADAM17CA2TP53MDM2 | |
| SCHEMBL4734177 | 0.79 | PPARA (0.31) | — | |
| SCHEMBL4738186 | 0.79 | CA12 (0.31) | CA2MMP14 | |
| SCHEMBL4737146 | 0.79 | TDP1 (0.36) | ADAM17CA2 | |
| SCHEMBL5067169 | 0.78 | MMP8 (0.33) | ADAM17CA2MMP8MMP14TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |