Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 17/20 | 0.40 |
| ▸ | PGR | P06401 | 3/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738893 | 0.77 | SMO (0.47) | NR3C1SMO | |
| SCHEMBL4735202 | 0.72 | DYRK1A (0.45) | — | |
| SCHEMBL10980321 | 0.68 | PPARA (0.47) | — | |
| SCHEMBL9058208 | 0.68 | PPARA (0.47) | — | |
| SCHEMBL10973888 | 0.68 | PPARA (0.47) | — | |
| SCHEMBL9059145 | 0.67 | PPARA (0.47) | — | |
| SCHEMBL4784046 | 0.65 | SMO (0.57) | NR3C1PGRSMO | |
| SCHEMBL4125598 | 0.64 | NR3C1 (0.42) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL4125595 | 0.64 | NR3C1 (0.42) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL30964022 | 0.64 | ESR1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079073-A1 | INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | disclosed |