Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.38 |
| ▸ | NEK2 | P51955 | 3/20 | 0.38 |
| ▸ | PLK1 | P53350 | 3/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738899 | 0.77 | DYRK1A (0.45) | DYRK1AMAPK1MAPK3CYP1A2AAK1 | |
| SCHEMBL4735199 | 0.72 | NR3C1 (0.40) | — | |
| SCHEMBL10980321 | 0.68 | PPARA (0.47) | — | |
| SCHEMBL9058208 | 0.68 | PPARA (0.47) | — | |
| SCHEMBL10973888 | 0.68 | PPARA (0.47) | — | |
| SCHEMBL9059145 | 0.67 | PPARA (0.47) | CYP1A2 | |
| SCHEMBL10771722 | 0.65 | CTSL (0.41) | — | |
| SCHEMBL10771726 | 0.65 | CTSL (0.41) | — | |
| SCHEMBL3712153 | 0.64 | MAPK1 (0.46) | DYRK1AMAPK1CYP1A2 | |
| SCHEMBL4006767 | 0.64 | LRRK2 (0.53) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079073-A1 | INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | disclosed |