Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | DNM1L | O00429 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739654 | 0.90 | LMNA (0.38) | MAPK14SMN1; SMN2LMNAMAPTMAPK1 | |
| SCHEMBL4737103 | 0.89 | GAA (0.43) | MAPK14SMN1; SMN2LMNAMAPTMAPK1 | |
| SCHEMBL4736625 | 0.86 | SMN1; SMN2 (0.39) | MAPK14SMN1; SMN2LMNAMAPTMAPK1 | |
| SCHEMBL4738953 | 0.86 | GAA (0.40) | SMN1; SMN2LMNAMAPTMAPK1HTT | |
| SCHEMBL3066236 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAMAPTMAPK1HTT | |
| SCHEMBL3061649 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAMAPTMAPK1HTT | |
| SCHEMBL3064198 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAMAPTMAPK1HTT | |
| SCHEMBL3829564 | 0.80 | ALDH1A1 (0.46) | LMNAMAPTHTTL3MBTL1GAA | |
| SCHEMBL4737001 | 0.80 | CYP3A4 (0.37) | SMN1; SMN2LMNAMAPTMAPK1HTT | |
| SCHEMBL3824906 | 0.80 | DNM1L (0.45) | MAPTDNM1LALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |