Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733795 | 0.93 | KDM4E (0.51) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL4738909 | 0.92 | TSHR (0.44) | LMNAKDM4EALDH1A1TSHRMAPK14 | |
| SCHEMBL4738924 | 0.90 | OPRM1 (0.40) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL4735426 | 0.90 | OPRM1 (0.43) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL4733666 | 0.89 | OPRM1 (0.49) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL4739086 | 0.89 | TSHR (0.52) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL4737014 | 0.88 | HDAC2 (0.42) | KDM4EALDH1A1TSHRMAPK14CXCR2 | |
| SCHEMBL4735549 | 0.88 | MEN1 (0.43) | KDM4EALDH1A1TSHRMAPK14MEN1 | |
| SCHEMBL4737659 | 0.88 | KDM4E (0.47) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL3826319 | 0.87 | DRD4 (0.47) | DRD4DRD2DRD3HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |