Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736577 | 0.90 | TSHR (0.49) | MEN1KMT2AATMMAPK14ALDH1A1 | |
| SCHEMBL4738909 | 0.89 | TSHR (0.44) | MEN1KMT2AMAPK14ALDH1A1KDM4E | |
| SCHEMBL4737305 | 0.88 | DRD4 (0.45) | MEN1KMT2AMAPK14ALDH1A1KDM4E | |
| SCHEMBL4733666 | 0.86 | OPRM1 (0.49) | MAPK14ALDH1A1KDM4ETSHRMAPT | |
| SCHEMBL4733795 | 0.86 | KDM4E (0.51) | MEN1KMT2AMAPK14ALDH1A1KDM4E | |
| SCHEMBL4739217 | 0.86 | MEN1 (0.42) | MEN1KMT2AATMMAPK14ALDH1A1 | |
| SCHEMBL4738924 | 0.85 | OPRM1 (0.40) | MEN1KMT2AMAPK14ALDH1A1KDM4E | |
| SCHEMBL4737659 | 0.85 | KDM4E (0.47) | MAPK14ALDH1A1KDM4ETSHROPRM1 | |
| SCHEMBL4735426 | 0.85 | OPRM1 (0.43) | MEN1KMT2AMAPK14ALDH1A1KDM4E | |
| SCHEMBL4740309 | 0.84 | LMNA (0.46) | MEN1KMT2AATMMAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |